Lithium enhances remyelination of peripheral nerves

Lithium enhances remyelination of peripheral nerves.

Glycogen synthase kinase 3β (GSK3β) inhibitors, especially the mood stabilizer lithium chloride, are also used as neuroprotective or anti-inflammatory agents. We studied the influence of LiCl on the remyelination of peripheral nerves. We showed that the treatment of adult mice with LiCl after facial nerve crush injury stimulated the expression of myelin genes, restored the myelin structure, and...

Axonal and Schwann cell BACE1 is equally required for remyelination of peripheral nerves.

Inhibition of β-site APP cleaving enzyme 1 (BACE1) is being pursued as a therapeutic target for treating patients with Alzheimer's disease because BACE1 is the sole β-secretase for generating β-amyloid peptide. Knowledge regarding the other cellular functions of BACE1 is therefore critical for the safe use of BACE1 inhibitors in human patients. BACE1 deficiency in mice causes hypomyelination du...

Injuries to Peripheral Nerves

the proximal to the distal segment. These cells may be formed by the breaking up of the myelon sheath, and it is asserted by some of the exponents of centrifugal regeneration that it is by means of these newly-organized myelon fragments that a chemical attraction is created which enables the new axons to find their way into the partly obliterated distal cord. All this doubt and speculation make...

Introduction of a New Suture Method in Repair of Peripheral Nerves Injured with a Sharp Mechanism

  Background: The standard method for repair of an injured peripheal nerve is epineural repair with separate sutures. Herein we describe a method in which the nerve is sutured with continous sutures. In fact this method has not been utilized for nerve repair previously and our purpose was to compare it to the standard method. If it proved to be successful it would replace the standard method in...

War Injuries of Peripheral Nerves.